Ms. Masango worked as a Junior Project Engineer but currently she is a PhD candidate in Nuclear Physics at The University of the Western cape. She was part of a major African led experiment at the European Organization for Nuclear Research (CERN) where she was the only woman in the group and received an honour to be the first African woman to be part of an African led experiment at CERN.
She is the founder and chairperson of Senamile Masango foundation. She is passionate about Science and Engineering and endeavor to empower women in Africa. The foundation offers programmes for middle school students to professionals, including a conference for middle and high school students, academic and career preparation programmes for college students, mentoring, internship, scholarships, a living-learning residential community and much more.
Senamile is the Leader of a research team representing South Africa at BRICS Youth Energy Agency. This is a volunteer international youth organisation established to secure cooperation of the youth from BRICS countries in the field of energy and to promote development of its research and scientific potential. She was part of the International Women's Conference hosted by South Africa's Parliament where she addressed issues that are faced by women in Africa.
Her past leadership roles include Deputy Secretary of Peace Aid International, Chairperson of Young African Women in Leadership, Chairperson of United African Youth as well as being an NEC member at Progressive Professionals Forum (PPF).
Some of her achievements include being one of South Africa's successful black woman Scientist under 35 years, 2019 Mail and Guardian 200 young South African Science and Technology.